Cerebrospinal Fluid Cytology

NAME OF PROCEDURE

Cerebrospinal Fluid Cytology

TEST CODE

NGYN

CPT CODE

88108 – Cytopathology, concentration technique, smears and interpretation

SYNONYMS

CSF, Spinal Fluid Cytology

APPLIES TO

Hydrocele Fluid Cytology, Lumbar Tap Cytology, Ventricular Tap Cytology

SPECIAL INSTRUCTIONS

Information regarding type of specimen, admitting diagnosis, and pertinent clinical history (i.e. age, clinical impression, past diagnosis, radiographic findings, and history of radiation or chemotherapy) is essential to interpretation and should be noted on the requisition.  Clinical evidence of immunosuppression should be indicated.  Special handling requirements (isolation) should be clearly noted on the requisition.

SPECIMEN

  • Fresh Cerebrospinal Fluid
  • Volume: 3-5mL
  • Minimum Volume:1mL

CONTAINER

Sterile tube from lumbar puncture tray or sterile disposable container. Please label submitted container(s) with a minimum of two patient identifiers.

COLLECTION TECHNIQUE

Collect Cerebrospinal fluid into sterile tube or sterile disposable container.

Label the specimen container or specimen tube with a minimum of two patient identifiers, date, and time of collection.

Deliver to the laboratory immediately.  Refrigerate specimen if immediate processing is not possible.  Do not add anticoagulant or fixative.

REQUEST FORM

Complete a Anatomical Pathology Requisition as indicated in the Test Ordering section of this manual. The patient information section as well as the Non-Gyn Cytology portion of the form should be completed.

CAUSES FOR REJECTION

Specimen container not properly labeled.

Grossly soiled/contaminated requisition or container.

LIMITATIONS

Malignant cells are shed to cerebrospinal fluid only from tumors which extend to subarachnoid space or into the ventricles. Metastatic tumors have a better detection rate than primary tumors.  Meningeal carcinomatosis or lymphoma may shed few cells, intermittently.

ADDITIONAL INFORMATION

Pneumoencephalography, myelography, radiation, or intrathecal therapy can all produce striking cytologic changes.

METHODOLOGY

Cytocentrifuge preparations are examined cytologically using the Pap stain method.

 

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